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Proceedings Paper

Dual energy iodine contrast imaging with mammography and tomosynthesis
Author(s): Baorui Ren; Chris Ruth; Yiheng Zhang; Andrew Smith; Don Kennedy; Bernadette O'Keefe; Ian Shaw; Cornell Williams; Zhen Ye; Elena Ingal; Brad Polischuk; Zhenxue Jing
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Paper Abstract

We have developed dual energy (DE) iodine contrast imaging functions with a commercial mammography and tomosynthesis system. Our system uses a tungsten target x-ray tube and selenium direct conversion detector. Conventional low energy (LE) images were acquired with existing Rh, Ag and Al filters at the screening doses while the high energy images (HE) were acquired with new Cu filters at half of the screening doses. In DE 2D mode, a pair of LE and HE images was taken with one second delay time between and with anti-scatter grid. In DE 3D mode, 22 views of alternating LE and HE were taken over 15 degrees angle in seven seconds without grid while tube was scanned continuously. We used log-subtraction algorithm to obtain clean DE images with the subtraction factor K derived empirically. In 3D mode, the subtraction was applied to each pair of LE and HE slices after reconstruction. The x-ray technique optimization was done with simulation and phantom study. We performed both phantom and patient studies to demonstrate the advantage of iodine contrast imaging. Among several new things in our work, a selenium detector optimized for DE imaging was tested and a large dose advantage was demonstrated; 2D and 3D DE images of a breast under same compression were acquired with a unique DE combo mode of the system, allowing direct image quality comparison between 2D and 3D modes. Our study showed that new DE system achieved good image quality. DE imaging is be a promising modality to detect breast cancer.

Paper Details

Date Published: 19 March 2013
PDF: 9 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86680U (19 March 2013); doi: 10.1117/12.2008147
Show Author Affiliations
Baorui Ren, Hologic Inc. (United States)
Chris Ruth, Hologic Inc. (United States)
Yiheng Zhang, Hologic Inc. (United States)
Andrew Smith, Hologic Inc. (United States)
Don Kennedy, Hologic Inc. (United States)
Bernadette O'Keefe, Hologic Inc. (United States)
Ian Shaw, Hologic Inc. (United States)
Cornell Williams, Hologic Inc. (United States)
Zhen Ye, Hologic Inc. (United States)
Elena Ingal, Hologic Inc. (United States)
Brad Polischuk, Hologic Inc. (United States)
Zhenxue Jing, Hologic Inc. (United States)


Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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