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Proceedings Paper

Intraoperative imaging for patient safety and QA: detection of intracranial hemorrhage using C-arm cone-beam CT
Author(s): Sebastian Schafer; Adam Wang; Yoshito Otake; J. Webster Stayman; Wojciech Zbijewski; Gerhard Kleinszig; Xuewei Xia; Gary L. Gallia; Jeffrey H. Siewerdsen
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Paper Abstract

Intraoperative imaging could improve patient safety and quality assurance (QA) via the detection of subtle complications that might otherwise only be found hours after surgery. Such capability could therefore reduce morbidity and the need for additional intervention. Among the severe adverse events that could be more quickly detected by high-quality intraoperative imaging is acute intracranial hemorrhage (ICH), conventionally assessed using post-operative CT. A mobile C-arm capable of high-quality cone-beam CT (CBCT) in combination with advanced image reconstruction techniques is reported as a means of detecting ICH in the operating room. The system employs an isocentric C-arm with a flat-panel detector in dual gain mode, correction of x-ray scatter and beam-hardening, and a penalized likelihood (PL) iterative reconstruction method. Performance in ICH detection was investigated using a quantitative phantom focusing on (non-contrast-enhanced) blood-brain contrast, an anthropomorphic head phantom, and a porcine model with injection of fresh blood bolus. The visibility of ICH was characterized in terms of contrast-to-noise ratio (CNR) and qualitative evaluation of images by a neurosurgeon. Across a range of size and contrast of the ICH as well as radiation dose from the CBCT scan, the CNR was found to increase from ~2.2-3.7 for conventional filtered backprojection (FBP) to ~3.9-5.4 for PL at equivalent spatial resolution. The porcine model demonstrated superior ICH detectability for PL. The results support the role of high-quality mobile C-arm CBCT employing advanced reconstruction algorithms for detecting subtle complications in the operating room at lower radiation dose and lower cost than intraoperative CT scanners and/or fixedroom C-arms. Such capability could present a potentially valuable aid to patient safety and QA.

Paper Details

Date Published: 15 March 2013
PDF: 6 pages
Proc. SPIE 8671, Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling, 86711X (15 March 2013); doi: 10.1117/12.2008043
Show Author Affiliations
Sebastian Schafer, Johns Hopkins Univ. (United States)
Adam Wang, Johns Hopkins Univ. (United States)
Yoshito Otake, Johns Hopkins Univ. (United States)
J. Webster Stayman, Johns Hopkins Univ. (United States)
Wojciech Zbijewski, Johns Hopkins Univ. (United States)
Gerhard Kleinszig, Siemens Healthcare (Germany)
Xuewei Xia, Johns Hopkins Univ. (United States)
Gary L. Gallia, Johns Hopkins Univ. (United States)
Jeffrey H. Siewerdsen, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 8671:
Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling
David R. Holmes; Ziv R. Yaniv, Editor(s)

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