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Proceedings Paper

Photoacoustic monitoring of clot formation during surgery and tumor surgery
Author(s): Mazen A. Juratli; Ekaterina I. Galanzha; Mustafa Sarimollaoglu; Dmitry A. Nedosekin; James Y. Suen; Vladimir P. Zharov
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Paper Abstract

When a blood vessel is injured, the normal physiological response of the body is to form a clot (thrombus) to prevent blood loss. Alternatively, even without injury to the blood vessel, the pathological condition called thromboembolism may lead to the formation of circulating blood clots (CBCs), also called emboli, which can clog blood vessels throughout the body. Veins of the extremities (venous thromboembolism), lungs (pulmonary embolism ), brain (embolic stroke), heart (myocardial infarction), kidneys, and gastrointestinal tract are often affected. Emboli are also common complications of infection, inflammation, cancer, surgery, radiation and coronary artery bypass grafts. Despite the clear medical significance of CBCs, however, little progress has been made in the development of methods for real-time detection and identification of CBCs. To overcome these limitations, we developed a new modification of in vivo photoacoustic (PA) flow cytometry (PAFC) for real-time detection of white, red, and mixed clots through a transient decrease, increase or fluctuation of PA signal amplitude, respectively. In this work, using PAFC and mouse models, we present for the first time direct evidence that some medical procedures, such as conventional or cancer surgery may initiate the formation of CBCs. In conclusion, the PA diagnostic platform can be used in real-time to define risk factors for cardiovascular diseases, assist in the prognosis and potential prevention of stroke by using a well-timed therapy or as a clot count as a marker of therapy efficacy.

Paper Details

Date Published: 4 March 2013
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814Q (4 March 2013); doi: 10.1117/12.2008035
Show Author Affiliations
Mazen A. Juratli, Univ. of Arkansas for Medical Sciences (United States)
Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (United States)
Mustafa Sarimollaoglu, Univ. of Arkansas for Medical Sciences (United States)
Dmitry A. Nedosekin, Univ. of Arkansas for Medical Sciences (United States)
James Y. Suen, Univ. of Arkansas for Medical Sciences (United States)
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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