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Proceedings Paper

Optimization of clinical protocols for contrast enhanced breast imaging
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Paper Abstract

Contrast enhanced (CE) breast imaging has been proposed as a method to increase the sensitivity and specificity of breast cancer detection. Because malignant lesions often exhibit angiogenesis, the uptake of radio-opaque contrast agents (e.g. iodine) results in increased attenuation compared to the background tissue. Both planar CE digital mammography (CE-DM) and digital breast tomosynthesis (CE-DBT) have been proposed, using temporal or dual energy (DE) subtraction to remove tissue backgrounds. In the current study, we apply a cascaded linear systems model approach to analyze CE techniques with DE subtraction for designing a diagnostic imaging study, including the effects of contrast dynamics. We apply the model for both CE-DM and CE-DBT to calculate the ideal observer signal-to-noise ratio (SNR) for the detection of I contrast objects of different sizes and concentrations. The calculation of this figure-of-merit (FOM) was be used to optimize CE clinical imaging protocols.

Paper Details

Date Published: 6 March 2013
PDF: 9 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86680G (6 March 2013); doi: 10.1117/12.2008028
Show Author Affiliations
Yue-Houng Hu, Stony Brook Health Sciences Ctr., SUNY (United States)
David A. Scaduto, Stony Brook Health Sciences Ctr., SUNY (United States)
Wei Zhao, Stony Brook Health Sciences Ctr., SUNY (United States)


Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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