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Proceedings Paper

Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment
Author(s): Samuel T. Keene; Albert E. Cerussi; Robert V. Warren; Brian Hill; Darren Roblyer; Anaїs Leproux; Amanda F. Durkin; Thomas D. O'Sullivan; Hosain Haghany; William W. Mantulin; Bruce J. Tromberg
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Paper Abstract

Instrument equivalence and quality control are critical elements of multi-center clinical trials. We currently have five identical Diffuse Optical Spectroscopic Imaging (DOSI) instruments enrolled in the American College of Radiology Imaging Network (ACRIN, #6691) trial located at five academic clinical research sites in the US. The goal of the study is to predict the response of breast tumors to neoadjuvant chemotherapy in 60 patients. In order to reliably compare DOSI measurements across different instruments, operators and sites, we must be confident that the data quality is comparable. We require objective and reliable methods for identifying, correcting, and rejecting low quality data. To achieve this goal, we developed and tested an automated quality control algorithm that rejects data points below the instrument noise floor, improves tissue optical property recovery, and outputs a detailed data quality report. Using a new protocol for obtaining dark-noise data, we applied the algorithm to ACRIN patient data and successfully improved the quality of recovered physiological data in some cases.

Paper Details

Date Published: 25 March 2013
PDF: 9 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85782M (25 March 2013); doi: 10.1117/12.2008009
Show Author Affiliations
Samuel T. Keene, Beckman Laser Institute and Medical Clinic (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Robert V. Warren, Beckman Laser Institute and Medical Clinic (United States)
Brian Hill, Beckman Laser Institute and Medical Clinic (United States)
Darren Roblyer, Beckman Laser Institute and Medical Clinic (United States)
Anaїs Leproux, Beckman Laser Institute and Medical Clinic (United States)
Amanda F. Durkin, Beckman Laser Institute and Medical Clinic (United States)
Thomas D. O'Sullivan, Beckman Laser Institute and Medical Clinic (United States)
Hosain Haghany, Beckman Laser Institute and Medical Clinic (United States)
William W. Mantulin, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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