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Proceedings Paper

Learning-based image preprocessing for robust computer-aided detection
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Paper Abstract

Recent studies have shown that low dose computed tomography (LDCT) can be an effective screening tool to reduce lung cancer mortality. Computer-aided detection (CAD) would be a beneficial second reader for radiologists in such cases. Studies demonstrate that while iterative reconstructions (IR) improve LDCT diagnostic quality, it however degrades CAD performance significantly (increased false positives) when applied directly. For improving CAD performance, solutions such as retraining with newer data or applying a standard preprocessing technique may not be suffice due to high prevalence of CT scanners and non-uniform acquisition protocols. Here, we present a learning-based framework that can adaptively transform a wide variety of input data to boost an existing CAD performance. This not only enhances their robustness but also their applicability in clinical workflows. Our solution consists of applying a suitable pre-processing filter automatically on the given image based on its characteristics. This requires the preparation of ground truth (GT) of choosing an appropriate filter resulting in improved CAD performance. Accordingly, we propose an efficient consolidation process with a novel metric. Using key anatomical landmarks, we then derive consistent feature descriptors for the classification scheme that then uses a priority mechanism to automatically choose an optimal preprocessing filter. We demonstrate CAD prototype performance improvement using hospital-scale datasets acquired from North America, Europe and Asia. Though we demonstrated our results for a lung nodule CAD, this scheme is straightforward to extend to other post-processing tools dedicated to other organs and modalities.

Paper Details

Date Published: 18 March 2013
PDF: 10 pages
Proc. SPIE 8670, Medical Imaging 2013: Computer-Aided Diagnosis, 867034 (18 March 2013); doi: 10.1117/12.2007925
Show Author Affiliations
Laks Raghupathi, Siemens Corp., Corporate Technology (India)
Pandu R. Devarakota, Siemens Corp., Corporate Technology (India)
Matthias Wolf, Siemens Healthcare, Inc. (United States)


Published in SPIE Proceedings Vol. 8670:
Medical Imaging 2013: Computer-Aided Diagnosis
Carol L. Novak; Stephen Aylward, Editor(s)

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