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Proceedings Paper

Scaling of photothermal effects accounting for localization of CW and pulse laser radiation within plasmonic nanoparticles
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Paper Abstract

A mathematical model and numerical simulation of nonstationary temperature field within tissues and cells locally heated under pulse laser irradiation mediated by plasmonic nanoparticles are presented. The essential temperature alterations during laser pulse and time interval between pulses was found. Temperature spatial-temporal profile depends on a number of parameters including optical and thermophysical properties of cell membrane and nanoparticles, laser wavelength, energy, pulse duration and repetition rate. On the basis of introduced parameters a quantitative evaluation of thermal effects was done. The possibilities of usage of these parameters to study their correlation with irreversible photothermal effects, including a change in the permeability of cell membrane during optoporation, are discussed.

Paper Details

Date Published: 1 March 2013
PDF: 7 pages
Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85801I (1 March 2013); doi: 10.1117/12.2007871
Show Author Affiliations
Alexander N. Yakunin, Institute of Precise Mechanics and Control (Russian Federation)
Yuri A. Avetisyan, Institute of Precise Mechanics and Control (Russian Federation)
Valery V. Tuchin, Institute of Precise Mechanics and Control (Russian Federation)
N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 8580:
Dynamics and Fluctuations in Biomedical Photonics X
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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