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Proceedings Paper

Magnetic nanoparticle hyperthermia: predictive model for temperature distribution
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Paper Abstract

Magnetic nanoparticle (mNP) hyperthermia is a promising adjuvant cancer therapy. mNP’s are delivered intravenously or directly into a tumor, and excited by applying an alternating magnetic field (AMF). The mNP’s are, in many cases, sequestered by cells and packed into endosomes. The proximity of the mNP’s has a strong influence on their ability to heat due to inter-particle magnetic interaction effects. This is an important point to take into account when modeling the mNP’s. Generally, more mNP heating can be achieved using higher magnetic field strengths. The factor which limits the maximum field strength applied to clinically relevant volumes of tissue is the heating caused by eddy currents, which are induced in the noncancerous tissue. A coupled electromagnetic and thermal model has been developed to predict dynamic thermal distributions during AMF treatment. The EM model is based on the method of auxiliary sources and the thermal modeling is based on the Pennes bioheat equation. The results of our phantom study are used to validate the model which takes into account nanoparticle heating, interaction effects, particle spatial distribution, particle size distribution, EM field distribution, and eddy current generation in a controlled environment. Preliminary in vivo data for model validation are also presented. Once fully developed and validated, the model will have applications in experimental design, AMF coil design, and treatment planning.

Paper Details

Date Published: 26 February 2013
PDF: 8 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858410 (26 February 2013); doi: 10.1117/12.2007673
Show Author Affiliations
Robert V. Stigliano, Thayer School of Engineering at Dartmouth (United States)
Fridon Shubitidze, Thayer School of Engineering at Dartmouth (United States)
Alicia A. Petryk, Thayer School of Engineering at Dartmouth (United States)
Jennifer A. Tate, Thayer School of Engineering at Dartmouth (United States)
P. Jack Hoopes, Thayer School of Engineering at Dartmouth (United States)
Dartmouth Medical School (United States)


Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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