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Proceedings Paper

An ultrasound-guided fluorescence tomography system: design and specification
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Paper Abstract

An ultrasound-guided fluorescence molecular tomography system is under development for in vivo quantification of Protoporphyrin IX (PpIX) during Aminolevulinic Acid - Photodynamic Therapy (ALA-PDT) of Basal Cell Carcinoma. The system is designed to combine fiber-based spectral sampling of PPIX fluorescence emission with co-registered ultrasound images to quantify local fluorophore concentration. A single white light source is used to provide an estimate of the bulk optical properties of tissue. Optical data is obtained by sequential illumination of a 633nm laser source at 4 linear locations with parallel detection at 5 locations interspersed between the sources. Tissue regions from segmented ultrasound images, optical boundary data, white light-informed optical properties and diffusion theory are used to estimate the fluorophore concentration in these regions. Our system and methods allow interrogation of both superficial and deep tissue locations up to PpIX concentrations of 0.025ug/ml.

Paper Details

Date Published: 13 March 2013
PDF: 8 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85681A (13 March 2013); doi: 10.1117/12.2007504
Show Author Affiliations
Alisha V. D'Souza, Thayer School of Engineering at Dartmouth (United States)
Brendan P. Flynn, Thayer School of Engineering at Dartmouth (United States)
Stephen C. Kanick, Thayer School of Engineering at Dartmouth (United States)
Sason Torosean, Thayer School of Engineering at Dartmouth (United States)
Scott C. Davis, Thayer School of Engineering at Dartmouth (United States)
Edward V. Maytin, Cleveland Clinic Lerner Research Institute (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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