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Proceedings Paper

Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment
Author(s): Alicia A. Petryk; Andrew J. Giustini; Rachel E. Gottesman; P. Jack Hoopes
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Paper Abstract

Most nanoparticle-based cancer therapeutic strategies seek to develop an effective individual cancer cell or metastatic tumor treatment. Critical to the success of these therapies is to direct as much of the agent as possible to the targeted tissue while avoiding unacceptable normal tissue complications. In this light, three different cisplatinum/magnetic nanoparticle (mNP) administration regimens were investigated. The most important finding suggests that clinically relevant doses of cisplatinum result in a significant increase in the tumor uptake of systemically delivered mNP. This enhancement of mNP tumor uptake creates the potential for an even greater therapeutic ratio through the addition of mNP based, intracellular hyperthermia.

Paper Details

Date Published: 26 February 2013
PDF: 7 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840H (26 February 2013); doi: 10.1117/12.2007308
Show Author Affiliations
Alicia A. Petryk, Thayer School of Engineering at Dartmouth (United States)
Andrew J. Giustini, Thayer School of Engineering at Dartmouth (United States)
Geisel School of Medicine (United States)
Rachel E. Gottesman, Geisel School of Medicine (United States)
P. Jack Hoopes, Thayer School of Engineering at Dartmouth (United States)
Geisel School of Medicine (United States)


Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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