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Proceedings Paper

3D micron-scale imaging of the cortical bone canal network in human osteogenesis imperfecta (OI)
Author(s): John R. Jameson; Carolyne I. Albert; Bjoern Busse; Peter A. Smith; Gerald F. Harris
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Paper Abstract

Osteogenesis imperfecta (OI) is a genetic disorder leading to increased bone fragility. Recent work has shown that the hierarchical structure of bone plays an important role in determining its mechanical properties and resistance to fracture. The current study represents one of the first attempts to characterize the 3D structure and composition of cortical bone in OI at the micron-scale. A total of 26 pediatric bone fragments from 18 individuals were collected during autopsy (Nc=5) or routing orthopaedic procedures (NOI=13) and imaged by microtomography with a synchrotron light source (SRμCT) for several microstructural parameters including cortical porosity (Ca.V/TV), canal surface to tissue volume (Ca.S/TV), canal diameter (Ca.Dm), canal separation (Ca.Sp), canal connectivity density (Ca.ConnD), and volumetric tissue mineral density (TMD). Results indicated significant differences in all imaging parameters between pediatric controls and OI tissue, with OI bone showing drastically increased cortical porosity, canal diameter, and connectivity. Preliminary mechanical testing revealed a possible link between cortical porosity and strength. Together these results suggest that the pore network in OI contributes greatly to its reduced mechanical properties.

Paper Details

Date Published: 29 March 2013
PDF: 9 pages
Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86721L (29 March 2013); doi: 10.1117/12.2007209
Show Author Affiliations
John R. Jameson, Lawrence Berkeley National Lab. (United States)
Marquette Univ. (United States)
Orthopaedic and Rehabilitation Engineering Ctr., Marquette Univ. (United States)
Carolyne I. Albert, Marquette Univ. (United States)
Orthopaedic and Rehabilitation Engineering Ctr., Marquette Univ. (United States)
Shriners Hospitals for Children (United States)
Bjoern Busse, Univ. Medical Ctr. Hamburg-Eppendorf (Germany)
Peter A. Smith, Orthopaedic and Rehabilitation Engineering Ctr., Marquette Univ. (United States)
Shriners Hospitals for Children (United States)
Gerald F. Harris, Marquette Univ. (United States)
Orthopaedic and Rehabilitation Engineering Ctr., Marquette Univ. (United States)
Shriners Hospitals for Children (United States)


Published in SPIE Proceedings Vol. 8672:
Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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