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Proceedings Paper

Breast density measurements using ultrasound tomography for patients undergoing tamoxifen treatment
Author(s): Mark Sak; Neb Duric; Peter Littrup; Cuiping Li; Lisa Bey-Knight; Mark Sherman; Norman Boyd; Gretchen Gierach
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Paper Abstract

Women with high breast density have an increased risk of developing breast cancer. Women treated with the selective estrogen receptor modulator tamoxifen for estrogen receptor positive breast cancer experience a 50% reduction in risk of contralateral breast cancer and overall reduction of similar magnitude has been identified among high-risk women receiving the drug for prevention. Tamoxifen has been shown to reduce mammographic density, and in the IBIS-1 chemoprevention trial, risk reduction and decline in density were significantly associated. Ultrasound tomography (UST) is an imaging modality that can create tomographic sound speed images of the breast. These sound speed images are useful because breast density is proportional to sound speed. The aim of this work is to examine the relationship between USTmeasured breast density and the use of tamoxifen. So far, preliminary results for a small number of patients have been observed and are promising. Correlations between the UST-measured density and mammographic density are strong and positive, while relationships between UST density with some patient specific risk factors behave as expected. Initial results of UST examinations of tamoxifen treated patients show that approximately 45% of the patients have a decrease in density in the contralateral breast after only several months of treatment. The true effect of tamoxifen on UST-measured density cannot yet be fully determined until more data are collected. However, these promising results suggest that UST can be used to reliably assess quantitative changes in breast density over short intervals and therefore suggest that UST may enable rapid assessment of density changes associated with therapeutic and preventative interventions.

Paper Details

Date Published: 29 March 2013
PDF: 10 pages
Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86751E (29 March 2013); doi: 10.1117/12.2007146
Show Author Affiliations
Mark Sak, Karmanos Cancer Institute (United States)
Neb Duric, Karmanos Cancer Institute (United States)
Delphinus Medical Technologies, Inc. (United States)
Peter Littrup, Karmanos Cancer Institute (United States)
Delphinus Medical Technologies, Inc. (United States)
Cuiping Li, Karmanos Cancer Institute (United States)
Delphinus Medical Technologies, Inc. (United States)
Lisa Bey-Knight, Karmanos Cancer Institute (United States)
Mark Sherman, National Cancer Institute (United States)
Norman Boyd, Princess Margaret Hospital (Canada)
Gretchen Gierach, National Cancer Institute (United States)


Published in SPIE Proceedings Vol. 8675:
Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
Johan G. Bosch; Marvin M. Doyley, Editor(s)

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