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Proceedings Paper

Automated 3D region-based volumetric estimation of optic disc swelling in papilledema using spectral-domain optical coherence tomography
Author(s): Jui-Kai Wang; Mohammad Saleh Miri; Randy H. Kardon; Mona K. Garvin
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Paper Abstract

The six-stage Frisén scale is a qualitative and subjective method for assessing papilledema (optic disc swelling due to raised intracranial pressure) using fundus photographs. The recent introduction of spectral-domain optical coherence tomography (SD-OCT) presents a promising alternative to enable the 3-D quantitative estimation of papilledema. In this work, we propose an automated region-based volumetric estimation of the degree of papilledema from SD-OCT. After using a custom graph-based approach to segment the surfaces of the swollen optic nerve head, the volumes of the nasal, superior, temporal, and inferior regions are computed. Using a dataset of 70 SD-OCT optic-nerve-head (ONH) SD-OCT scans the Spearman rank correlation coefficients between expert-defined Frisén scale grades and the total retinal (TR) volume, nasal, superior, temporal, inferior regional volumes were 0.737, 0.752, 0.747, 0.770 and 0.758, respectively. Also, a fuzzy k-nearest-neighbor (k-NN) algorithm was used to predict Frisén scale grades (in a leave-one-subject-out fashion). Using multiple features rather than just the TR volume made the resulting mean Frisén grade difference (MGD) between the expert-defined grades 0.386 (down from 0.629) and prediction accuracy 64.29% (up from 41.43%).

Paper Details

Date Published: 29 March 2013
PDF: 8 pages
Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 867214 (29 March 2013); doi: 10.1117/12.2007001
Show Author Affiliations
Jui-Kai Wang, The Univ. of Iowa (United States)
Mohammad Saleh Miri, The Univ. of Iowa (United States)
Randy H. Kardon, The Univ. of Iowa (United States)
VA Ctr. for the Prevention and Treatment of Visual Loss (United States)
Mona K. Garvin, The Univ. of Iowa (United States)
VA Ctr. for the Prevention and Treatment of Visual Loss (United States)


Published in SPIE Proceedings Vol. 8672:
Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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