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Proceedings Paper

Computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas
Author(s): Shang Wang; Narendran Sudheendran; Chih-Hao Liu; Ravi Kiran Manapuram; Valery P. Zakharov; Davis R. Ingram; Alexander J. Lazar; Dina C. Lev; Raphael E. Pollock; Kirill V. Larin
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Paper Abstract

We present a computational method for the analysis of optical coherence tomography (OCT) images to detect soft tissue sarcomas. The method combines the quantitative analysis of two aspects of information from the intensity A-lines of OCT images; one is the slope of the intensity A-line with dB unit, which is determined by the optical attenuation characteristics of tissue; the other is the standard deviation (SD) of the slope-removed intensity A-line, which is dependent on the tissue structural features. The method is tested with pilot experiments on ex vivo tissue samples of human fat, muscle, well differentiated liposarcoma (WDLS) and leiomyosarcoma. Our results demonstrate the feasibility of this quantitative method in the differentiation of soft tissue sarcomas from normal tissues. This study indicates that OCT can be a potential computer-aided means of automatically and accurately identifying resection margins of soft tissues sarcomas during surgical treatment.

Paper Details

Date Published: 1 March 2013
PDF: 7 pages
Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85800T (1 March 2013); doi: 10.1117/12.2006638
Show Author Affiliations
Shang Wang, Univ. of Houston (United States)
Narendran Sudheendran, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Ravi Kiran Manapuram, Univ. of Houston (United States)
Valery P. Zakharov, Samara State Aerospace Univ. (Russian Federation)
Davis R. Ingram, The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Alexander J. Lazar, The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Dina C. Lev, The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Raphael E. Pollock, The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 8580:
Dynamics and Fluctuations in Biomedical Photonics X
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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