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Proceedings Paper

Characterizing fluidic seals for on-board reagent delivery
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Paper Abstract

The reagent delivery mechanism in a point-of-care, HIV diagnostic, microfluidic device is studied. Reagents held in an aluminum blister pack are released on the opening of a fluidic seal. The fluidic seals, controlling the flow of reagents, are characterized to reduce anomalies in the desired flow pattern. The findings of this research can be divided into three categories – 1) bonding phenomenon 2) influence of seal pattern on flow and rupture mechanics and 3) process parameters which minimize flow anomalies. Four seal patterns – line hemisphere, line flat, chevron hemisphere and chevron flat were created and tested for reagent delivery using a flow sensor and a force gauge. Experiments suggest that one of the patterns – line-flat – inducted the fewest flow anomalies. A parameter scoping exercise of the seal manufacturing process parameters (temperature, time, pressure) was performed for the line flat seal. Temperature, time, pressure / gap and distance settings which minimize flow anomalies were found.

Paper Details

Date Published: 9 March 2013
PDF: 6 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 861516 (9 March 2013); doi: 10.1117/12.2006257
Show Author Affiliations
Tejas Inamdar, Massachusetts Institute of Technology (United States)
Brian W. Anthony, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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