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Proceedings Paper

Programming paper networks for point of care diagnostics
Author(s): Shivani Dharmaraja; Lisa Lafleur; Samantha Byrnes; Peter Kauffman; Josh Buser; Bhushan Toley; Elain Fu; Paul Yager; Barry Lutz
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Paper Abstract

Lateral flow tests (LFTs) are well-suited for rapid point-of-care testing in low resource settings. The wicking action of the paper strip moves the sample and reagents through the device without a need for pumps, but LFTs are typically limited to tests that can be carried out in a single fluidic step. The materials from LFTs can be reconfigured to create paper networks that automatically carry out multi-step fluidic operations, while retaining the same easy-to-use format as a conventional LFT. Here, we describe basic principles of wicking and system-level behavior of paper networks by analogy to electrical circuits. We describe key design principles for a previously-developed 2D paper network (2DPN) and introduce an alternative linear paper network (Pseudo-1DPN) that takes advantage of system-level behavior to perform clean sequential fluid delivery while reducing device running time.

Paper Details

Date Published: 9 March 2013
PDF: 11 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150X (9 March 2013); doi: 10.1117/12.2006138
Show Author Affiliations
Shivani Dharmaraja, The Univ. of Washington (United States)
Lisa Lafleur, The Univ. of Washington (United States)
Samantha Byrnes, The Univ. of Washington (United States)
Peter Kauffman, The Univ. of Washington (United States)
Josh Buser, The Univ. of Washington (United States)
Bhushan Toley, The Univ. of Washington (United States)
Elain Fu, The Univ. of Washington (United States)
Paul Yager, The Univ. of Washington (United States)
Barry Lutz, The Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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