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Proceedings Paper

On alterations in the refractive index and scattering properties of biological tissue caused by histological processing
Author(s): Htet Aung; Bianca DeAngelo; John Soldano; Piotr Kostyk; Braulio Rodriguez; M. Xu
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Paper Abstract

Clinical tissue processing such as formalin fixing, paraffin-embedding and histological staining alters significantly the optical properties of the tissue. We document the alterations in the optical properties of prostate cancer tissue specimens in the 500nm to 700nm spectral range caused by histological processing with quantitative differential interference contrast (qDIC) microscopy. A simple model to explain these alterations is presented at the end.

Paper Details

Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8592, Biomedical Applications of Light Scattering VII, 85920X (21 February 2013); doi: 10.1117/12.2005927
Show Author Affiliations
Htet Aung, Fairfield Univ. (United States)
Bianca DeAngelo, Fairfield Univ. (United States)
John Soldano, Fairfield Univ. (United States)
Piotr Kostyk, Fairfield Univ. (United States)
Braulio Rodriguez, Fairfield Univ. (United States)
M. Xu, Fairfield Univ. (United States)

Published in SPIE Proceedings Vol. 8592:
Biomedical Applications of Light Scattering VII
Adam P. Wax; Vadim Backman, Editor(s)

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