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Proceedings Paper

The study of esophageal cancer in an early stage by using Raman spectroscopy
Author(s): Mika Ishigaki; Akinori Taketani; Yasuhiro Maeda; Bibin B. Andriana; Ryu Ishihara; Hidetoshi Sato
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Paper Abstract

The esophageal cancer is a disease with a high mortality. In order to lead a higher survival rate five years after the cancer’s treatment, we inevitably need a method to diagnose the cancer in an early stage and support the therapy. Raman spectroscopy is one of the most powerful techniques for the purpose. In the present study, we apply Raman spectroscopy to obtain ex vivo spectra of normal and early tumor human esophageal sample. The result of principal component analysis indicates that the tumor tissue is associated with a decrease in tryptophan concentration. Furthermore, we can predict the tissue type with 80% accuracy by linear discriminant analysis which model is made by tryptophan bands.

Paper Details

Date Published: 25 February 2013
PDF: 6 pages
Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 859109 (25 February 2013); doi: 10.1117/12.2005662
Show Author Affiliations
Mika Ishigaki, Kwansei Gakuin Univ. (Japan)
Akinori Taketani, Kwansei Gakuin Univ. (Japan)
Yasuhiro Maeda, Kwansei Gakuin Univ. (Japan)
Bibin B. Andriana, Kwansei Gakuin Univ. (Japan)
Ryu Ishihara, Osaka Medical Ctr. for Cancer and Cardiovascular Diseases (Japan)
Hidetoshi Sato, Kwansei Gakuin Univ. (Japan)

Published in SPIE Proceedings Vol. 8591:
Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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