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Proceedings Paper

Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength
Author(s): Farshid Ghasemi; Ali A. Eftekhar; David S. Gottfried; Xuezheng Song; Richard D. Cummings; Ali Adibi
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Paper Abstract

We report on application of on-chip referencing to improve the limit-of-detection (LOD) in compact silicon nitride (SiN) microring arrays. Microring resonators, fabricated by e-beam lithography and fluorine-based etching, are designed for visible wavelengths (656nm) and have a footprint of 20 x 20 μm. GM1 ganglioside is used as the specific ligand for recognition of Cholera Toxin Subunit B (CTB), with Ricinus Communis Agglutinin I (RCA I) as a negative control. Using micro-cantilever based printing less than 10 pL of glycan solution is consumed per microring. Real-time data on analyte binding is extracted from the shifts in resonance wavelengths of the microrings.

Paper Details

Date Published: 19 February 2013
PDF: 9 pages
Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 85940A (19 February 2013); doi: 10.1117/12.2005653
Show Author Affiliations
Farshid Ghasemi, Georgia Institute of Technology (United States)
Ali A. Eftekhar, Georgia Institute of Technology (United States)
David S. Gottfried, Georgia Institute of Technology (United States)
Xuezheng Song, Emory Univ. School of Medicine (United States)
Richard D. Cummings, Emory Univ. School of Medicine (United States)
Ali Adibi, Georgia Institute of Technology (United States)


Published in SPIE Proceedings Vol. 8594:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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