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Proceedings Paper

Diagnosing breast cancer using independent diffuse optical tomography and x-ray mammography scans
Author(s): Maxim Fradkin; Matthias C. Hofmann; Jean-Michel Rouet; Richard H. Moore; Daniel B. Kopans; Keith Tipton; Sankar Suryanarayanan; David A. Boas; Qianqian Fang
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Paper Abstract

We have previously demonstrated the utilization of spatially co-registered diffuse optical tomography (DOT) and digital breast tomosynthesis (DBT) for joint breast cancer diagnosis. However, clinical implementation of such a multi-modality approach may require development of integrated DOT/DBT imaging scanners, which can be costly and time-consuming. Exploring effective image registration methods that combine the diagnostic information from a standalone DOT measurement and a separate mammogram can be a cost-effective solution, which may eventually enable adding functional optical assessment to all previously installed digital mammography systems. In this study, we investigate a contour-based image registration method to convert independent optical and x-ray scans into co-registered datasets that can benefit from a joint image analysis. The breast surface used in 3D optical DOT reconstruction is registered with the breast contour line extracted from an x-ray mammogram acquired separately. This allows us to map the 2D mammogram to the optical measurement space and build structural constraints for optical image reconstruction. A non-linear reconstruction utilizing structure-priors is then performed to produce hemoglobin maps with improved resolution. To validate this approach, we used a set of tumor patient measurements with simultaneous DOT/DBT and separate 2D mammographic scans. The images recovered from the registration procedure derived from DOT and 2D mammogram present similar image quality compared to those recovered from co-registered DOT/DBT measurements.

Paper Details

Date Published: 13 March 2013
PDF: 8 pages
Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740G (13 March 2013); doi: 10.1117/12.2005649
Show Author Affiliations
Maxim Fradkin, Philips France (France)
Matthias C. Hofmann, Massachusetts General Hospital (United States)
Jean-Michel Rouet, Philips France (France)
Richard H. Moore, Massachusetts General Hospital (United States)
Daniel B. Kopans, Massachusetts General Hospital (United States)
Keith Tipton, Philips Healthcare, N.A. (United States)
Sankar Suryanarayanan, Philips Healthcare, N.A. (United States)
David A. Boas, Massachusetts General Hospital (United States)
Qianqian Fang, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 8574:
Multimodal Biomedical Imaging VIII
Fred S. Azar; Xavier Intes, Editor(s)

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