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Proceedings Paper

Trigger effect of infrared femtosecond laser irradiation on neoplasm in experimental cervical cancer
Author(s): Tatyana Gening; Olga Voronova; Igor Zolotovskii; Alexey Sysoliatin; Dinara Dolgova; Tatyana Abakumova
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Paper Abstract

The present work discusses effect of infrared (IR) femtosecond laser irradiation on neoplasm of white mice with experimental cervical cancer- 5 (CC-5 on the 20th and 30th days after tumor transplantation). Tumor tissue was irradiated by femtosecond erbium doped fiber laser: the wavelength is 1.55 μm, average and peak powers are1,25 mW and 6kW, respectively, irradiation trials n=10. The average energy density (energy dose) on a tissue for two groups of animals was 0,24 J/cm2 and 0,36 J/cm2 for a single trial. Irradiation was followed by biochemical determination of LPO AOS parameters (“Lipid peroxidation-antioxidants” system): malondialdehyde (MDA), activity of superoxide dismutase (SOD), catalase and glutathione-reductase (GR), glutathione-S-transferase (GST). A subsequent morphological study of tumor tissue was performed. Mathematical analysis of data demonstrates a weak dependence of the studied parameters on energy dose. The latter implies the trigger effect of IR femtosecond laser irradiation on redox-dependent processes in neoplasm at experimental cervical cancer.

Paper Details

Date Published: 15 February 2013
PDF: 9 pages
Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790I (15 February 2013); doi: 10.1117/12.2005625
Show Author Affiliations
Tatyana Gening, Ulyanovsk State Univ. (Russian Federation)
Olga Voronova, Ulyanovsk State Univ. (Russian Federation)
Igor Zolotovskii, Ulyanovsk State Univ. (Russian Federation)
Alexey Sysoliatin, Fiber Optics Research Ctr. (Russian Federation)
Dinara Dolgova, Ulyanovsk State Univ. (Russian Federation)
Tatyana Abakumova, Ulyanovsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 8579:
Optical Interactions with Tissue and Cells XXIV
E. Duco Jansen; Robert J. Thomas, Editor(s)

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