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Proceedings Paper

Preclinical dosimetry of magnetic fluid hyperthermia for bladder cancer
Author(s): Tiago R. Oliveira; Paul R. Stauffer; Chen-Ting Lee; Chelsea Landon; Wiguins Etienne; Paolo F. Maccarini; Brant Inman; Mark W. Dewhirst
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Paper Abstract

Background Despite positive efficacy, thermotherapy is not widely used in clinical oncology. Difficulties associated with field penetration and controlling power deposition patterns in heterogeneous tissue have limited its use for heating deep in the body. Heat generation using iron-oxide super-paramagnetic nanoparticles excited with magnetic fields has been demonstrated to overcome some of these limitations. The objective of this preclinical study is to investigate the feasibility of treating bladder cancer with magnetic fluid hyperthermia (MFH) by analyzing the thermal dosimetry of nanoparticle heating in a rat bladder model. Methods The bladders of 25 female rats were injected with 0.4 ml of Actium Biosystems magnetite-based nanoparticles (Actium Biosystems, Boulder CO) via catheters inserted in the urethra. To assess the distribution of nanoparticles in the rat after injection we used the 7 T small animal MRI system (Bruker ClinScan, Bruker BioSpin MRI GmbH, Ettlingen, Germany). Heat treatments were performed with a small animal magnetic field applicator (Actium Biosystems, Boulder CO) with a goal of raising bladder temperature to 42°C in <10min and maintaining for 60min. Temperatures were measured throughout the rat with seven fiberoptic temperature probes (OpSens Technologies, Quebec Canada) to characterize our ability to localize heat within the bladder target. Results The MRI study confirms the effectiveness of the catheterization procedure to homogenously distribute nanoparticles throughout the bladder. Thermal dosimetry data demonstrate our ability to controllably raise temperature of rat bladder >1°C/min to a steady-state of 42°C. Conclusion Our data demonstrate that a MFH system provides well-localized heating of rat bladder with effective control of temperature in the bladder and minimal heating of surrounding tissues.

Paper Details

Date Published: 26 February 2013
PDF: 10 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840D (26 February 2013); doi: 10.1117/12.2005623
Show Author Affiliations
Tiago R. Oliveira, Duke Univ. (United States)
Univ. de São Paulo (Brazil)
Paul R. Stauffer, Duke Univ. (United States)
Chen-Ting Lee, Duke Univ. (United States)
Chelsea Landon, Duke Univ. (United States)
Wiguins Etienne, Duke Univ. (United States)
Paolo F. Maccarini, Duke Univ. (United States)
Brant Inman, Duke Univ. (United States)
Mark W. Dewhirst, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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