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Proceedings Paper

Real-time treatment feedback guidance of Pleural PDT
Author(s): Timothy C. Zhu; Michele M. Kim; Xing Liang; Baochang Liu; Julia L. Meo; Jarod C. Finlay; Andreea Dimofte; Carmen Rodriguez; Charles Simone; Keith Cengel; Joseph Friedberg
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Paper Abstract

Pleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for mesothelioma with remarkable results. In the current intrapleural PDT protocol, a moving fiber-based point source is used to deliver the light and the light dose are monitored by 7 detectors placed in the pleural cavity. To improve the delivery of light dose uniformity, an infrared (IR) camera system is used to track the motion of the light sources. A treatment planning system uses feedback from the detectors as well as the IR camera to update light fluence distribution in real-time, which is used to guide the light source motion for uniform light dose distribution. We have improved the GUI of the light dose calculation engine to provide real-time light fluence distribution suitable for guiding the surgery to delivery light more uniformly. A dual-correction method is used in the feedback system, so that fluence calculation can match detector readings using both direct and scatter light models. An improved measurement device is developed to automatically acquire laser position for the point source. Comparison of the effects of the guidance is presented in phantom study.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680O (13 March 2013); doi: 10.1117/12.2005603
Show Author Affiliations
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Michele M. Kim, Univ. of Pennsylvania (United States)
Xing Liang, Univ. of Pennsylvania (United States)
Baochang Liu, Univ. of Pennsylvania (United States)
Julia L. Meo, Univ. of Pennsylvania (United States)
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Andreea Dimofte, Univ. of Pennsylvania (United States)
Carmen Rodriguez, Univ. of Pennsylvania (United States)
Charles Simone, Univ. of Pennsylvania (United States)
Keith Cengel, Univ. of Pennsylvania (United States)
Joseph Friedberg, Penn Presbyterian Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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