Share Email Print
cover

Proceedings Paper

Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment
Author(s): Kristen Herrmann; Yong-Eun Lee Koo; Daniel A. Orringer; Oren Sagher; Martin Philbert; Raoul Kopelman
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Photosensitizer-conjugated polyacrylamide nanoparticles were prepared for in vivo characterization of the minimally invasive and localized treatment of photodynamic therapy (PDT) on brain tumors. By incorporating a variety of nanoparticle matrixes, choosing methylene blue as a photosensitizer, and targeting the nanoparticle by the use of F3 peptide we have made nanoparticle-based PDT improvements to current PDT efficiency. Quantitative growth patterns were determined through visual observation of the tumorigenic response to various treatments by the use of an animal cranial window model. PDT treatments with methylene blue-polyacrylamide (MB-PAA) nanoparticles produced significant adjournment of tumor growth over control groups, clearly demonstrating the advantages of nanoparticle-based PDT agents for the eradication of local tumors, leading to the potential palliation of the advancing disease.

Paper Details

Date Published: 13 March 2013
PDF: 8 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680I (13 March 2013); doi: 10.1117/12.2005530
Show Author Affiliations
Kristen Herrmann, The Univ. of Michigan (United States)
Yong-Eun Lee Koo, The Univ. of Michigan (United States)
Daniel A. Orringer, The Univ. of Michigan (United States)
Oren Sagher, The Univ. of Michigan (United States)
Martin Philbert, The Univ. of Michigan (United States)
Raoul Kopelman, The Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

© SPIE. Terms of Use
Back to Top