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Proceedings Paper

Combined photothermal therapy and chemotherapy in cancer using HER-2 targeted PLGA nanoparticles
Author(s): Anthony J McGoron; Supriya Srinivasan; Tingjun Lei; Yuan Tang; Romila Manchanda
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Paper Abstract

We previously reported on the synergistic effects of hyperthermia and chemotherapy using doxorubicin (DOX) and Indocyanine Green (ICG). In a previous study we also explored the potential use of simultaneous entrapment of optical/imaging and chemotherapeutic agents into PLGA nanoparticles. The aim of the present study is to further decorate their surface with tumor specific monoclonal antibodies in order to achieve simultaneous therapy and diagnosis in a targeted manner. Thus, ICG was selected as an imaging agent due to its wide clinical applications and since it can also serve as hyperthermia agent. DOX was selected as the chemotherapeutic agent since it is used clinically for a large spectrum of tumors.

Paper Details

Date Published: 21 February 2013
PDF: 6 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820B (21 February 2013); doi: 10.1117/12.2005500
Show Author Affiliations
Anthony J McGoron, Florida International Univ. (United States)
Supriya Srinivasan, Florida International Univ. (United States)
Tingjun Lei, Florida International Univ. (United States)
Yuan Tang, Temple Univ. (United States)
Romila Manchanda, Florida International Univ. (United States)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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