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Proceedings Paper

Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging
Author(s): L. Sudheendra; Gautom K. Das; C. Li; Simon R. Cherry; Ian M. Kennedy
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Paper Abstract

Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

Paper Details

Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960D (21 February 2013); doi: 10.1117/12.2005250
Show Author Affiliations
L. Sudheendra, Univ. of California, Davis (United States)
Gautom K. Das, Univ. of California, Davis (United States)
C. Li, Univ. of California, Davis (United States)
Univ. of California, Merced (United States)
Simon R. Cherry, Univ. of California, Davis (United States)
Ian M. Kennedy, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 8596:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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