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Proceedings Paper

OCT imaging in chronic obstructive pulmonary disease
Author(s): K. Ohtani; R. M. Lopez Lisbona; A. M. D. Lee; C. Hyun; T. Shaipanich; A. McWilliams; P. Lane; H. O. Coxson; C. MacAulay; S. Lam
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Paper Abstract

Introduction: A recent ex-vivo study using micro-CT in patients with chronic obstructive pulmonary disease (COPD) showed that narrowing and disappearance of small conducting airways precedes the onset of emphysematous destruction in COPD. Until recently, the airway remodeling process could not be studied in detail in-vivo. In this study, we investigated the repeatability of navigating an Optical Coherence Tomography (OCT) catheter to image the same airways in smokers with and without COPD. Method: OCT imaging was performed by inserting the catheter through a sub-segmental airway to a small bronchiole. Three-dimensional OCT imaging of 5 cm of airway segments was obtained. The catheter was removed and reinsertion into the same airway was attempted. The number of airway generations and quantitative measurements of the airway wall area were investigated. Results: Sixty-three airways in 30 subjects were analyzed. Repeated insertion into the same airway was observed at 53.8 %, 92.3% and 70.8% of the time in the upper, middle and lower lobes respectively. The percentage differences of paired measurements of airway wall area between matched and unmatched airways in bronchioles were 5.8 ± 4.6 % and 7.3 ± 5.4 % respectively Conclusions: Repeated OCT imaging of airways is possible in the majority of cases except in the upper lobes. For airways that are not completely matched, some of the airway segments can still be used for comparison by careful alignment of the airway. OCT may be a useful method to study the remodeling process in small airways and the effect of therapeutic intervention.

Paper Details

Date Published: 8 March 2013
PDF: 8 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85652T (8 March 2013); doi: 10.1117/12.2005206
Show Author Affiliations
K. Ohtani, The BC Cancer Research Ctr. (Canada)
R. M. Lopez Lisbona, The BC Cancer Research Ctr. (Canada)
A. M. D. Lee, The BC Cancer Research Ctr. (Canada)
C. Hyun, The BC Cancer Research Ctr. (Canada)
T. Shaipanich, The BC Cancer Research Ctr. (Canada)
A. McWilliams, The BC Cancer Research Ctr. (Canada)
P. Lane, The BC Cancer Research Ctr. (Canada)
H. O. Coxson, Vancouver General Hospital (Canada)
C. MacAulay, The BC Cancer Research Ctr. (Canada)
S. Lam, The BC Cancer Research Ctr. (Canada)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory; Guillermo J. Tearney; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen; E. Duco Jansen; Justus F. Ilgner; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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