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Proceedings Paper

Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia
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Paper Abstract

We present a dynamic contrast-enhanced near-infrared (DCE-NIR) technique that is capable of non-invasive quantification of cerebral hemodynamics in adults. The challenge of removing extracerebral contamination is overcome through the use of multi-distance time-resolved DCE-NIR combined with the kinetic deconvolution optical reconstruction (KDOR) analytical method. As proof-of-principle, cerebral blood flow, cerebral blood volume and mean transit time recovered with DCE-NIR are compared with CT perfusion values in an adult pig during normocapnia, hypocapnia, and ischemia. Measurements of blood flow acquired with DCE-NIR were compared against concomitant measurements using CT Perfusion.

Paper Details

Date Published: 25 March 2013
PDF: 7 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780A (25 March 2013); doi: 10.1117/12.2005128
Show Author Affiliations
Jonathan T. Elliott, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Mamadou Diop, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Laura B. Morrison, Lawson Health Research Institute (Canada)
Ting-Yim Lee, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Keith St. Lawrence, Lawson Health Research Institute (Canada)
Western Univ. (Canada)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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