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Proceedings Paper

Hierarchical clustering method for improved prostate cancer imaging in diffuse optical tomography
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Paper Abstract

We investigate the feasibility of trans-rectal near infrared (NIR) based diffuse optical tomography (DOT) for early detection of prostate cancer using a transrectal ultrasound (TRUS) compatible imaging probe. For this purpose, we designed a TRUS-compatible, NIR-based image system (780nm), in which the photo diodes were placed on the trans-rectal probe. DC signals were recorded and used for estimating the absorption coefficient. We validated the system using laboratory phantoms. For further improvement, we also developed a hierarchical clustering method (HCM) to improve the accuracy of image reconstruction with limited prior information. We demonstrated the method using computer simulations laboratory phantom experiments.

Paper Details

Date Published: 25 March 2013
PDF: 7 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781K (25 March 2013); doi: 10.1117/12.2005105
Show Author Affiliations
Venkaiah C. Kavuri, The Univ. of Texas at Arlington (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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