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Proceedings Paper

Noninvasive imaging of absolute PpIX concentration distribution in nonmelanoma skin tumors at pre-PDT
Author(s): Ulas Sunar; Daniel Rohrbach; Janet Morgan; Natalie Zeitouni
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Paper Abstract

Photodynamic Therapy (PDT) has proven to be an effective treatment option for nonmelanoma skin cancers. The ability to quantify the concentration of drug in the treated area is crucial for effective treatment planning as well as predicting outcomes. We utilized spatial frequency domain imaging for quantifying the accurate concentration of protoporphyrin IX (PpIX) in phantoms and in vivo. We correct fluorescence against the effects of native tissue absorption and scattering parameters. First we quantified the absorption and scattering of the tissue non-invasively. Then, we corrected raw fluorescence signal by compensating for optical properties to get the absolute drug concentration. After phantom experiments, we used basal cell carcinoma (BCC) model in Gli mice to determine optical properties and drug concentration in vivo at pre-PDT.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680C (13 March 2013); doi: 10.1117/12.2005078
Show Author Affiliations
Ulas Sunar, Roswell Park Cancer Institute (United States)
Daniel Rohrbach, Roswell Park Cancer Institute (United States)
Janet Morgan, Roswell Park Cancer Institute (United States)
Natalie Zeitouni, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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