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Proceedings Paper

Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent
Author(s): Xin Cai; Lina Wu; Wenxin Xing; Jun Xia; Liming Nie; Ruiying Zhang; Gregory M. Lanza; Baozhong Shen; Dipanjan Pan; Lihong V. Wang
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Paper Abstract

We demonstrated the potential of carbon nanoparticles (CNPs) as exogenous contrast agents for both thermoacoustic (TA) tomography (TAT) and photoacoustic (PA) tomography (PAT). In comparison to deionized water, the CNPs provided a four times stronger signal in TAT at 3 GHz. In comparison to blood, The CNPs provided a much stronger signal in PAT over a broad wavelength range of 450-850 nm. Specifically, the maximum signal enhancement in PAT was 9.4 times stronger in the near-infrared window of 635-670 nm. In vivo blood-vessel PA imaging was performed non-invasively on a mouse femoral area. The images, captured after the tail vein injection of CNPs, show a gradual enhancement of the optical absorption in the vessels by up to 230%. The results indicate that CNPs can be potentially used as contrast agents for TAT and PAT to monitor the intravascular or extravascular pathways in clinical applications.

Paper Details

Date Published: 4 March 2013
PDF: 5 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858140 (4 March 2013); doi: 10.1117/12.2005064
Show Author Affiliations
Xin Cai, Washington Univ. in St. Louis (United States)
Lina Wu, Washington Univ. School of Medicine (United States)
4th Affiliated Hospital of Harbin Medical Univ. (China)
Wenxin Xing, Washington Univ. in St. Louis (United States)
Jun Xia, Washington Univ. in St. Louis (United States)
Liming Nie, Washington Univ. in St. Louis (United States)
Ruiying Zhang, Washington Univ. in St. Louis (United States)
Gregory M. Lanza, Washington Univ. School of Medicine (United States)
Baozhong Shen, 4th Affiliated Hospital of Harbin Medical Univ. (China)
Dipanjan Pan, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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