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Proceedings Paper

A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry
Author(s): Daniel J. Rohrbach; Andrew Kowalczewski; Bouri Chen; Ulas Sunar
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Paper Abstract

Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856815 (13 March 2013); doi: 10.1117/12.2005051
Show Author Affiliations
Daniel J. Rohrbach, Roswell Park Cancer Institute (United States)
Andrew Kowalczewski, Roswell Park Cancer Institute (United States)
Bouri Chen, Roswell Park Cancer Institute (United States)
Ulas Sunar, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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