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Proceedings Paper

Monitoring PDT response of head and neck lesions with diffuse optical spectroscopies
Author(s): Daniel J. Rohrbach; Nestor Rigual; Erin Tracy; Ken Keymel; Michele T. Cooper; Heinz Baumann; Barbara W. Henderson; Ulas Sunar
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Paper Abstract

Photodynamic therapy (PDT) has recently emerged as a potential treatment alternative for head and neck cancer. There is strong evidence that imprecise PDT dosimetry results in variations in clinical responses. Quantitative tools are likely to play an essential role in bringing PDT to a full realization of its potential benefits. They can provide standardization of site-specific individualized protocols that are used to monitor both light and photosensitizer (HPPH) dose, as well as the tissue response for individual patients. To accomplish this, we used a custom instrument and a hand-held probe that allowed quantification of blood flow, blood volume, blood oxygen saturation and drug concentration.

Paper Details

Date Published: 13 March 2013
PDF: 7 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 856814 (13 March 2013); doi: 10.1117/12.2005024
Show Author Affiliations
Daniel J. Rohrbach, Roswell Park Cancer Institute (United States)
Nestor Rigual, Roswell Park Cancer Institute (United States)
Erin Tracy, Roswell Park Cancer Institute (United States)
Ken Keymel, Roswell Park Cancer Institute (United States)
Michele T. Cooper, Roswell Park Cancer Institute (United States)
Heinz Baumann, Roswell Park Cancer Institute (United States)
Barbara W. Henderson, Roswell Park Cancer Institute (United States)
Ulas Sunar, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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