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Proceedings Paper

Dynamic optical breast imaging for neoadjuvant therapy monitoring
Author(s): Amir Y. Sajjadi; Christy M. Wanyo; Qianqian Fang; David A. Boas; Steven J. Isakoff; Stefan A. Carp
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Paper Abstract

Near-infrared optical measurements have been shown to offer a promising non-invasive way for monitoring breast neoadjuvant chemotherapy (NAC) and predicting outcome. In this study, we extend optical measurements to capture additional hemodynamic and metabolic biomarkers revealed by dynamically imaging breast tissue during fractional mammographic compression. We are obtaining pre-treatment, day 7 and optional monthly scans in breast cancer patients undergoing NAC. The difference in hemodynamic response to compression between healthy and tumor-bearing breast decreases over the course of neoadjuvant therapy in responders compared to nearly no change in patients not responding to the chemotherapy.

Paper Details

Date Published: 25 March 2013
PDF: 8 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780I (25 March 2013); doi: 10.1117/12.2004884
Show Author Affiliations
Amir Y. Sajjadi, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Christy M. Wanyo, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Qianqian Fang, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
David A. Boas, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Steven J. Isakoff, Massachusetts General Hospital (United States)
Stefan A. Carp, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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