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Proceedings Paper

Evaluation of Fourier transform coefficients for the diagnosis of rheumatoid arthritis from diffuse optical tomography images
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Paper Abstract

We apply the Fourier Transform to absorption and scattering coefficient images of proximal interphalangeal (PIP) joints and evaluate the performance of these coefficients as classifiers using receiver operator characteristic (ROC) curve analysis. We find 25 features that yield a Youden index over 0.7, 3 features that yield a Youden index over 0.8, and 1 feature that yields a Youden index over 0.9 (90.0% sensitivity and 100% specificity). In general, scattering coefficient images yield better one-dimensional classifiers compared to absorption coefficient images. Using features derived from scattering coefficient images we obtain an average Youden index of 0.58 ± 0.16, and an average Youden index of 0.45 ± 0.15 when using features from absorption coefficient images.

Paper Details

Date Published: 25 March 2013
PDF: 6 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781N (25 March 2013); doi: 10.1117/12.2004846
Show Author Affiliations
Ludguier D. Montejo, Columbia Univ. (United States)
Jingfei Jia, Columbia Univ. (United States)
Hyun K. Kim, Columbia Univ. Medical Ctr. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)
Columbia Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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