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Proceedings Paper

Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates
Author(s): Yan Xu; Saeid Zanganeh; Innus Mohammad; Andres Aguirre; Tianheng Wang; Yi Yang; Liisa Kuhn; Michael Smith; Quing Zhu
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Paper Abstract

In this paper, we have synthesized a second generation tumor hypoxia targeted 2-nitroimidazole-ICG conjugate using piperazine linker (2-nitro-ICG-p) and validated its performance in in vivo tumor targeting. The results have shown that tumor hypoxia can be targeted with twice higher signal strength beyond three hours post-injection while the un-targeted ICG has completely washed out. The improvement of the second generation 2-nitro-ICG-p dyes is 1.2-1.3 times over the first generation 2-nitro-ICG dyes using ethanol linker beyond 3 hours post-injection which is the optimal time-window for evaluating tumor hypoxia.

Paper Details

Date Published: 25 March 2013
PDF: 7 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781Z (25 March 2013); doi: 10.1117/12.2004767
Show Author Affiliations
Yan Xu, Univ. of Connecticut (United States)
Saeid Zanganeh, Univ. of Connecticut (United States)
Innus Mohammad, Univ. of Connecticut (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Tianheng Wang, Univ. of Connecticut (United States)
Yi Yang, Univ. of Connecticut (United States)
Liisa Kuhn, Univ. of Connecticut Health Ctr. (United States)
Michael Smith, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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