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Proceedings Paper

Video-rate photoacoustic microscopy of micro-vasculatures
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Paper Abstract

We report the development of photoacoustic microscopy capable of video-rate high-resolution in-vivo imaging in deep tissue. A lightweight photoacoustic probe is made of a single-element broadband ultrasound transducer, a compact photoacoustic beam combiner, and a bright-field light delivery system. Focused broadband ultrasound detection provides a 44-μm lateral resolution and a 28-μm axial resolution. A multimode optical fiber is used to deliver laser pulses. The bright-field light delivery system can effectively improve the illumination efficiency. The photoacoustic probe weighs less than 40 grams and is mounted on a voice-coil scanner to acquire 40 cross-sectional images per second over several-mm range. The fast speed can effectively improve imaging throughput, reduce motion artifacts, and enable the visualization of highly dynamic biomedical processes. High-resolution micro-vascular imaging is successfully demonstrated.

Paper Details

Date Published: 4 March 2013
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811T (4 March 2013); doi: 10.1117/12.2004714
Show Author Affiliations
Lidai Wang, Washington Univ. in St. Louis (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Wenxin Xing, Washington Univ. in St. Louis (United States)
Alejandro Garcia-Uribe, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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