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Proceedings Paper

4D display of the outflow track of embryonic-chick hearts (HH 14-19) using a high speed streak mode OCT
Author(s): Siyu Ma; Rui Wang; Richard L. Goodwin; Roger R. Markwald; Thomas K. Borg; Raymond B. Runyan; Zhi Gao
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Paper Abstract

Congenital Heart Disease (CHD) is the most common congenital malformation in newborns in the US. Although knowledge of CHD is limited, altered hemodynamic conditions are suspected as the factor that stimulates cardiovascular cell response, resulting in the heart morphology remodeling that ultimately causes CHDs. Therefore, one of recent efforts in CHD study is to develop high-speed imaging tools to correlate the rapidly changing hemodynamic condition and the morphological adaptations of an embryonic heart in vivo. We have developed a high-speed streak mode OCT that works at the center wavelength of 830 nm and is capable of providing images (292x220 μm2) of the outflow tract of an embryonic chick heart at the rate of 1000 Hz. The modality can provide a voxel resolution in the range of 10 μm3, and the spectral resolution allows a depth range of 1.63 mm. In the study reported here, each of the 4D images of an outflow tract was recorded for 2 seconds. The recording was conducted every 2 hours (HH17 to HH18), 3 hours (HH14 to HH17), and 4 hours (HH18 to HH19). Because of the fast scan speed, there is no need for postacquisition processing such as use of gating techniques to provide a fine 3D structure. In addition, more details of the outflow tract are preserved in the recorded images. The 4D images can be used in the future to determine the role of blood flow in CHD development.

Paper Details

Date Published: 1 March 2013
PDF: 8 pages
Proc. SPIE 8580, Dynamics and Fluctuations in Biomedical Photonics X, 85801G (1 March 2013); doi: 10.1117/12.2004588
Show Author Affiliations
Siyu Ma, Clemson Univ. (United States)
Rui Wang, Clemson Univ. (United States)
Richard L. Goodwin, Univ. of South Carolina (United States)
Roger R. Markwald, Medical Univ. of South Carolina (United States)
Thomas K. Borg, Medical Univ. of South Carolina (United States)
Raymond B. Runyan, Univ. of Arizona (United States)
Zhi Gao, Clemson Univ. (United States)

Published in SPIE Proceedings Vol. 8580:
Dynamics and Fluctuations in Biomedical Photonics X
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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