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Proceedings Paper

Monitoring changes in tissue optical properties following interstitial photothermal therapy of ex vivo human prostate tissue
Author(s): Robert A. Weersink; Jie He; Israel Veilleux; John Trachtenberg; Brian C. Wilson
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Paper Abstract

We are developing a method of monitoring treatment progression of interstitial photothermal therapy of focal prostate cancer using transrectal diffuse optical tomography (TRDOT) combined with transrectal 3D ultrasound (3D-TRUS). Measurements of prostate tissue optical properties were made on ex vivo human prostate samples prior to and post coagulation. Interstitial photothermal treatments were delivered to the ex vivo samples and monitored using an interstitial probe near the treatment fiber. After treatment, bulk optical properties were measured on native and coagulated zones of tissue. Changes in optical properties across the boundary between native and coagulated tissues were spatially mapped using a small diffuse reflectance probe. The optical property estimates and spatial information obtained using each method was compared.

Paper Details

Date Published: 25 March 2013
PDF: 8 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781G (25 March 2013); doi: 10.1117/12.2004578
Show Author Affiliations
Robert A. Weersink, Univ. Health Network (Canada)
Jie He, Princess Margaret Cancer Ctr. (Canada)
Israel Veilleux, Princess Margaret Cancer Ctr. (Canada)
John Trachtenberg, Princess Margaret Cancer Ctr. (Canada)
Brian C. Wilson, Princess Margaret Cancer Ctr. (Canada)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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