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Proceedings Paper

Continuous wave terahertz reflection imaging of human colorectal tissue
Author(s): Pallavi Doradla; Karim Alavi; Cecil S. Joseph; Robert H. Giles
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Paper Abstract

Continuous wave terahertz (THz) imaging has the potential to offer a safe, non-ionizing, and nondestructive medical imaging modality for delineating colorectal cancer. Fresh excisions of normal colon tissue were obtained from surgeries performed at the University of Massachusetts Medical School, Worcester. Reflection measurements of thick sections of colorectal tissues, mounted in an aluminum sample holder, were obtained for both fresh and formalin fixed tissues. The two-dimensional reflection images were acquired by using an optically pumped far-infrared molecular gas laser operating at 584 GHz with liquid Helium cooled silicon bolometer detector. Using polarizers in the experiment both co-polarized and cross-polarized remittance form the samples was collected. Analysis of the images showed the importance of understanding the effects of formalin fixation while determining reflectance level of tissue response. The resulting co- and cross-polarized images of both normal and formalin fixed tissues showed uniform terahertz response over the entire sample area. Initial measurements indicated a co-polarized reflectance of 16%, and a cross-polarized reflectance of 0.55% from fresh excisions of normal colonic tissues.

Paper Details

Date Published: 27 March 2013
PDF: 7 pages
Proc. SPIE 8624, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VI, 86240O (27 March 2013); doi: 10.1117/12.2004385
Show Author Affiliations
Pallavi Doradla, The Univ. of Massachusetts Lowell (United States)
Karim Alavi, The Univ. of Massachusetts Medical School (United States)
Cecil S. Joseph, The Univ. of Massachusetts Lowell (United States)
Robert H. Giles, The Univ. of Massachusetts Lowell (United States)

Published in SPIE Proceedings Vol. 8624:
Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VI
Laurence P. Sadwick; Créidhe M. O'Sullivan, Editor(s)

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