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Proceedings Paper

Stationary microfluidics: molecular diagnostic assays by moving magnetic beads through non-moving liquids
Author(s): Holger Becker; Cornelia Carstens; Dirk Kuhlmeier; Natalia Sandetskaya; Nicole Schröter; Christian Zilch; Claudia Gärtner
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Paper Abstract

Commonly, microfluidic devices are based on the movement of fluids. For molecular diagnostics assays which often include steps like PCR, this practically always involves a more or less complicated set of external pumps, valves and liquid controls. In the presented paper, we follow a different approach in which the fluid after sample introduction remains stationary and the main bioactive sample molecules are moved through a chain of reaction compartments which contain the different reagents necessary for the assay. The big advantage of this concept is the lack of any external fluid actuation/control. Results on sample carry-over experiments and complete assays will be given.

Paper Details

Date Published: 13 March 2013
PDF: 5 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150B (13 March 2013); doi: 10.1117/12.2004041
Show Author Affiliations
Holger Becker, microfluidic ChipShop GmbH (Germany)
Cornelia Carstens, microfluidic ChipShop GmbH (Germany)
Dirk Kuhlmeier, Fraunhofer-Institut für Zelltherapie und Immunologie (Germany)
Natalia Sandetskaya, Fraunhofer-Institut für Zelltherapie und Immunologie (Germany)
Nicole Schröter, Magna Diagnostics GmbH (Germany)
Christian Zilch, Magna Diagnostics GmbH (Germany)
Claudia Gärtner, microfluidic ChipShop GmbH (Germany)


Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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