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Proceedings Paper

Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model
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Paper Abstract

We present frequency-resolved measurements of the amplitude and phase of cerebral hemodynamic oscillations associated with paced breathing and measured with near-infrared spectroscopy on the forehead of a human subject. We have performed measurements at eleven paced breathing frequencies in the range 0.07-0.25 Hz. The resulting frequency spectra of the amplitude and phase of the hemodynamic oscillations were fit with a recently developed hemodynamic model,1 that was able to reproduce the measured spectra and to determine a number of associated physiological parameters. The parameters measured include the blood transit times in the capillary (0.87 s) and venous (1.0 s) compartments, and the high-pass cutoff frequency of cerebral autoregulation (0.087 Hz). We also illustrate the implications of the new hemodynamic model on the basis of a phasor representation of physiological and hemodynamic oscillations. The combination of frequency-resolved measurements of cerebral hemodynamics and the phasor-based, frequency-domain solution of the new hemodynamic model provides a novel tool for cerebral hemodynamic studies with a potential for assessing a variety of physiological, functional, and pathological conditions.

Paper Details

Date Published: 25 March 2013
PDF: 7 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780C (25 March 2013); doi: 10.1117/12.2003873
Show Author Affiliations
Michele L. Pierro, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Bertan Hallacoglu, Tufts Univ. (United States)
Jana M. Kainerstorfer, Tufts Univ. (United States)
Sergio Fantini, Tufts Univ. (United States)


Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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