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Proceedings Paper

Sensing cocaine in saliva with infrared laser spectroscopy
Author(s): Kerstin M.-C. Hans; Matthias Müller; Michele Gianella; Ph. Wägli; Markus W. Sigrist
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Paper Abstract

Increasing numbers of accidents caused by drivers under the influence of drugs, raise drug tests to worldwide interest. We developed a one-step extraction technique for cocaine in saliva and analyzed reference samples with laser spectroscopy employing two different schemes. The first is based on attenuated total reflection (ATR), which is applied to dried samples. The second scheme uses transmission measurements for the analysis of liquid samples. ATR spectroscopy achieved a limit of detection (LOD) of 3μg/ml. The LOD for the transmission approach in liquid samples is < 10 μg/ml. These LODs are realistic as such concentration ranges are encountered in the saliva of drug users after the administration of a single dose of cocaine. An improved stabilization of the set-up should lower the limit of detection significantly.

Paper Details

Date Published: 22 February 2013
PDF: 7 pages
Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910F (22 February 2013); doi: 10.1117/12.2003615
Show Author Affiliations
Kerstin M.-C. Hans, ETH Zurich (Switzerland)
Matthias Müller, ETH Zurich (Switzerland)
Michele Gianella, ETH Zurich (Switzerland)
Ph. Wägli, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Markus W. Sigrist, ETH Zurich (Switzerland)


Published in SPIE Proceedings Vol. 8591:
Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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