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Proceedings Paper

Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system
Author(s): Alex T. Luk; Yuting Lin; Brian Grimmond; Anup Sood; Egidijus E. Uzgiris; Orhan Nalcioglu; Gultekin Gulsen
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Paper Abstract

Since diffuse optical tomography (DOT) is a low spatial resolution modality, it is desirable to validate its quantitative accuracy with another well-established imaging modality, such as magnetic resonance imaging (MRI). In this work, we have used a polymer based bi-functional MRI-optical contrast agent (Gd-DTPA-polylysine-IR800) in collaboration with GE Global Research. This multi-modality contrast agent provided not only co-localization but also the same kinetics, to cross-validate two imaging modalities. Bi-functional agents are injected to the rats and pharmacokinetics at the bladder are recovered using both optical and MR imaging. DOT results are validated using MRI results as "gold standard"

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740K (13 March 2013); doi: 10.1117/12.2003606
Show Author Affiliations
Alex T. Luk, Univ. of California, Irvine (United States)
Yuting Lin, Univ. of California, Irvine (United States)
Brian Grimmond, GE Global Research (United States)
Anup Sood, GE Global Research (United States)
Egidijus E. Uzgiris, Rensselaer Polytechnic Institute (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 8574:
Multimodal Biomedical Imaging VIII
Fred S. Azar; Xavier Intes, Editor(s)

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