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Proceedings Paper

Neurostimulation using subnanosecond electric pulses
Author(s): Shu Xiao; Andrei Pakhomov; Fei Guo; Swetha Polisetty; Karl H. Schoenbach
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Paper Abstract

We have for the first time recorded action potentials in rat hippocampus neurons when they were stimulated by subnanosecond electric pulses. The preliminary results show that applying a series of pulses allowed the accumulation of depolarization before activating the voltage gated channels. The depolarization only occurred when the electric pulses were applied. It is unclear whether the depolarization is caused by the charge accumulation across the membrane or the cation influx due to the membrane permeabilization. We have also conducted an electromagnetic simulation of delivering subnanosecond pulses to tissues using an impulse radiating antenna. The results show that the pulses can be confined in the deep region in the brain but the amplitude is reduced significantly due to the attenuation of the tissues. A partially lossy dielectric lens may be used to reverse the decreasing trend of the electric field.

Paper Details

Date Published: 23 February 2013
PDF: 6 pages
Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850M (23 February 2013); doi: 10.1117/12.2003341
Show Author Affiliations
Shu Xiao, Frank Reidy Research Ctr. for Bioelectrics, Old Dominion Univ. (United States)
Andrei Pakhomov, Frank Reidy Research Ctr. for Bioelectrics, Old Dominion Univ. (United States)
Fei Guo, Frank Reidy Research Ctr. for Bioelectrics, Old Dominion Univ. (United States)
Swetha Polisetty, Old Dominion Univ. (United States)
Karl H. Schoenbach, Frank Reidy Research Ctr. for Bioelectrics, Old Dominion Univ. (United States)


Published in SPIE Proceedings Vol. 8585:
Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications
Gerald J. Wilmink; Bennett L. Ibey, Editor(s)

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