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Proceedings Paper

Lab-in-fiber platform for plasmonic photothermal study
Author(s): Derrick Yong; Elizabeth Lee; Wei Long Ng; Xia Yu; Chi Chiu Chan
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Paper Abstract

A lab-in-fiber platform, comprising a photonic crystal fiber component for light-sample interaction, was experimentally demonstrated to be effective as a sensor and micro-reactor. Specifically, it enabled the discrimination between free and liposome-encapsulated fluorophores as well as allowed for the excitation of in-fiber plasmonic photothermal effects, by alternating between different fiber-coupled inputs. The significant increase in fluorescence emissions upon release of fluorophores, encapsulated within liposomes at self-quenching concentrations, was perceived as a shoulder in the device’s spectral output that otherwise only comprises the input excitation. Markedly, the observed shoulder was only discernible when the photonic crystal fiber was placed in a bent orientation. This was explained to be associated with the bending-induced refractive index profile changes in the fiber cross section that led to increased amounts of evanescent fields for light-sample interactions. Results highlighted the viability of the lab-in-fiber platform as an alternative to current lab-on-a-chip devices.

Paper Details

Date Published: 9 March 2013
PDF: 8 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 861504 (9 March 2013); doi: 10.1117/12.2003335
Show Author Affiliations
Derrick Yong, A*STAR Singapore Institute of Manufacturing Technology (Singapore)
Nanyang Technological Univ. (Singapore)
Elizabeth Lee, A*STAR Singapore Institute of Manufacturing Technology (Singapore)
Nanyang Technological Univ. (Singapore)
Wei Long Ng, A*STAR Singapore Institute of Manufacturing Technology (Singapore)
Nanyang Technological Univ. (Singapore)
Xia Yu, A*STAR Singapore Institute of Manufacturing Technology (Singapore)
Chi Chiu Chan, Nanyang Technological Univ. (Singapore)


Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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