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Proceedings Paper

Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release
Author(s): Jie Cao; Shanshan Huang; Yuqi Chen; Siwen Li; Samuel Achilefu; Zhiyu Qian; Yueqing Gu
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Paper Abstract

In this manuscript, a new near-infrared (NIR) light-breakable amphiphilic block copolymer containing light-sensitive triggering group on the hydrophobic block was developed. By encapsulating NIR dye cypate inside micelles of poly (N-succinyl-N'-4- (2-nitrobenzyloxy)-succinyl chitosan) and exposing the micellar solution to 765.9 nm light, the photo-cleavage reaction was activated and leading to the dissociation of micelles and release of co-loaded hydrophobic species. The UV-vis absorption spectra, fourier transform infrared (FTIR) spectra and 1H nuclear magnetic resonance (1H NMR) spectra of micelles were characterized. Triggered burst release of the payload upon NIR irradiation and subsequent degradation of the micelles were observed by transmission electron microscopy (TEM). This system represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.

Paper Details

Date Published: 21 February 2013
PDF: 7 pages
Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 859606 (21 February 2013); doi: 10.1117/12.2003247
Show Author Affiliations
Jie Cao, China Pharmaceutical Univ. (China)
Shanshan Huang, China Pharmaceutical Univ. (China)
Yuqi Chen, China Pharmaceutical Univ. (China)
Siwen Li, China Pharmaceutical Univ. (China)
Samuel Achilefu, Washington Univ. in St. Louis (United States)
Zhiyu Qian, Nanjing Univ. of Aeronautics and Astronautics (China)
Yueqing Gu, China Pharmaceutical Univ. (China)


Published in SPIE Proceedings Vol. 8596:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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