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Proceedings Paper

Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate
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Paper Abstract

Time-resolved fluorescence was used to investigate malignant and normal adjacent breast tissues stained with a conjugate of indocyanine green and octreotate. A marked increase in fluorescence lifetime intensity was seen in the breast cancer sample compared to the normal sample. The fluorescent lifetimes were also investigated and showed similar fluorescence decay curves in stained malignant and normal breast tissue. These results confirm that somatostatin receptors occur on human breast carcinomas, suggest that the presence of somatostatin receptors should be investigated as a marker of breast cancer aggressiveness, and suggest that this conjugate might be used to detect the presence of residual breast cancer after surgery, allowing better assessment of tumor margins and reducing the need for second or repeat biopsies in selected patients. These results may also provide clues for designing future treatment options for breast cancer patients.

Paper Details

Date Published: 19 March 2013
PDF: 6 pages
Proc. SPIE 8577, Optical Biopsy XI, 857708 (19 March 2013); doi: 10.1117/12.2003102
Show Author Affiliations
Laura A. Sordillo, The City College of New York (United States)
B. B. Das, Fairfield Univ. (United States)
Yang Pu, The City College of New York (United States)
Kexian Liang, Washington Univ. School of Medicine in St. Louis (United States)
Giovanni Milione, The City College of New York (United States)
Peter P. Sordillo, The City College of New York (United States)
Sam Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
R. R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 8577:
Optical Biopsy XI
Robert R. Alfano; Stavros G. Demos, Editor(s)

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