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Proceedings Paper

Microcavity single virus detection and sizing with molecular sensitivity
Author(s): V. R. Dantham; S. Holler; V. Kolchenko; Z. Wan; S. Arnold
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Paper Abstract

We report the label-free detection and sizing of the smallest individual RNA virus, MS2 by a spherical microcavity. Mass of this virus is ~6 ag and produces a theoretical resonance shift ~0.25 fm upon adsorbing an individual virus at the equator of the bare microcavity, which is well below the r.m.s background noise of 2 fm. However, detection was accomplished with ease (S/N = 8, Q = 4x105) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer. Analytical expressions based on the “reactive sensing principle” are developed to extract the radius of the virus from the measured signals. Estimated limit of detection for these experiments was ~0.4 ag or 240 kDa below the size of all known viruses, largest globular and elongated proteins [Phosphofructokinase (345 kDa) and Fibrinogen (390 kDa), respectively].

Paper Details

Date Published: 22 February 2013
PDF: 6 pages
Proc. SPIE 8600, Laser Resonators, Microresonators, and Beam Control XV, 86001P (22 February 2013); doi: 10.1117/12.2003098
Show Author Affiliations
V. R. Dantham, Polytechnic Institute of New York Univ. (United States)
S. Holler, Polytechnic Institute of New York Univ. (United States)
Fordham Univ. (United States)
V. Kolchenko, New York City College of Technology (United States)
Z. Wan, Hunter College (United States)
S. Arnold, Polytechnic Institute of New York Univ. (United States)

Published in SPIE Proceedings Vol. 8600:
Laser Resonators, Microresonators, and Beam Control XV
Alexis V. Kudryashov; Alan H. Paxton; Vladimir S. Ilchenko; Lutz Aschke; Kunihiko Washio, Editor(s)

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