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Proceedings Paper

Polyacrylamide based ICG nanocarriers for enhanced fluorescence and photoacoustic imaging
Author(s): Aniruddha Ray; Hyung Ki Yoon; HeeJu Ryu; Yong-Eun Koo Lee; Gwangseong Kim; Xueding Wang; Raoul Kopelman
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Paper Abstract

Indocyanine green (ICG) is an FDA approved tricarbocyanine dye. This dye, with a strong absorbance in the near infrared (NIR) region, has been extensively used for fluorescence and photoacoustic imaging in vivo. ICG in its free form, however, has a few drawbacks that limit its in vivo applications, such as non-targetability, tendency to form aggregates which changes its optical properties, fast degradation, short plasma lifetime and reduced fluorescence at body temperature. In order to bypass these inherent drawbacks, we demonstrate a polyacrylamide based nanocarrier that was particularly designed to carry the negatively charged ICG molecules. These nanocarriers are biodegradable, biocompatible and can be specifically targeted to any cell or tissue. Using these nanocarriers we avoid all the problems associated with free ICG, such as degradation, aggregation and short plasma lifetime, and also enhance demonstrate its ability towards photoacoustics and fluorescence imaging.

Paper Details

Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960P (21 February 2013); doi: 10.1117/12.2002921
Show Author Affiliations
Aniruddha Ray, Univ. of Michigan (United States)
Hyung Ki Yoon, Univ. of Michigan (United States)
HeeJu Ryu, Univ. of Michigan (United States)
Yong-Eun Koo Lee, Univ. of Michigan (United States)
Gwangseong Kim, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 8596:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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